Registration Dossier
Registration Dossier
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EC number: 203-801-5 | CAS number: 110-76-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethoxyethylamine
- EC Number:
- 203-801-5
- EC Name:
- 2-ethoxyethylamine
- Cas Number:
- 110-76-9
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethoxyethylamine
- Details on test material:
- - Name of test material (as cited in study report): 2-Aethoxyaethylamin
- Analytical purity: 98 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.0 kg (mean)
- Diet: Ssniff
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the adjacent eye served as saline control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- 8 days
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h - 48 h - 72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
Any other information on results incl. tables
The application of the test substance caused corrosion to the exposed eyes predominantly expressed by severe corneal opacity and chemosis.
Severe corneal opacity is considered to be an irreversible effect to ophthalmic tissue.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
