2-ethoxyethylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented publication which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Principles of method if other than guideline:

BASF-Test

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethylamine

EC Number:

203-801-5

EC Name:

2-ethoxyethylamine

Cas Number:

110-76-9

Molecular formula:

C4H11NO

IUPAC Name:

2-ethoxyethylamine

Details on test material:

- Name of test material (as cited in study report): 2-Aethoxyaethylamin
- Analytical purity: 98 %

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: WIGA, Sulzfeld
- Weight at study initiation: 185±15 g
- Diet: Herilan MRH (Eggersmann KG, Rinteln) ad libitum
- Water: tap water ad libitum

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose/head only

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

yes

Remarks:

gas chromatography

Duration of exposure:

4 h

Concentrations:

7.61 mg/l (analytic); 9.78 (nominal)

No. of animals per sex per dose:

10

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 7.61 mg/L air (analytical)

Exp. duration:

4 h

Mortality:

No mortality occured

Clinical signs:

other: Red eye and nose discharge, dyspnoea, high stepping gait, ruffled fur, irregular respiration,

Body weight:

No differences in weight gain between male control and treated animals. In treated females a slightly decreased weight gain was noted.

Gross pathology:

Sporadic foam cell granuloma.

Any other information on results incl. tables

Body weight in (g):

Dose (mg/kg)	day 0		day 7		day 14
	male	female	male	female	male	female
control	193	183	235	201	257	206
7.61	189	183	222	185	257	194

There is indication that the test substace caused local irritation to exposed tissues including the respiratory tract.