Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-829-1 | CAS number: 4090-51-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A bacterial mutagenicity test, performed according to OECD guideline 471 (RL1) is available, showing no mutagenic activity. This is supported by several less reliable studies (RL2) with the same results in bacteria and also in yeast.
Also, no mutagenic response was observed in mammalian cells in vitro (HPRT-test, RL1).
One reliable in vivo study is available (RL2), which examined the induction of micronuclei after oral exposure to mice. Based on these consistent negative results, no further testing is required.
Short description of key information:
No mutagenic effects were observed in any of the available in vitro studies in bacteria and mammalian cells, supported by Ames-tests from less reliable studies. One reliable in vivo study did not observe the induction of micronuclei in mice.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the findings of reliable studies in vitro and in vivo, the test substance has not to be classified for genotoxic effects according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
