2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1977

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Short communication with limited data documetation

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Type of study / information:

Test on inhibition of cholinesterase activity

Principles of method if other than guideline:

enzyme test

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide

EC Number:

223-829-1

EC Name:

2,2'-oxybis[5,5-dimethyl-1,3,2-dioxaphosphorinane] 2,2'-disulphide

Cas Number:

4090-51-1

Molecular formula:

C10H20O5P2S2

IUPAC Name:

2,2'-oxybis(5,5-dimethyl-1,3,2-dioxaphosphinane) 2,2'-disulfide

Results and discussion

Any other information on results incl. tables

The test item was insoluble in usual solvents. It was tested in acetone aqueous suspension and did not inhibit the activity of the cholinesterase up to the highest tested concentration of 1 x 10epx-2 M. Parathion was used as positive control and showed an IC50 of 2-4 x 10exp-4 M.