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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable study report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1963
Report date:
1963

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,6-dichlorohexane
EC Number:
218-491-7
EC Name:
1,6-dichlorohexane
Cas Number:
2163-00-0
Molecular formula:
C6H12Cl2
IUPAC Name:
1,6-dichlorohexane
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
other: Bethesda-Black
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: watery emulsion with traganth
Doses:
0.2, 1.6, 2.0, 2.5, 3.2 or 6.4 mL/kg (214, 1710, 2138, 2673, 3421 and 6842 mg/kg bw)
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 2 675 mg/kg bw
Remarks on result:
other: original value: about 2.5 mL/kg bw
Mortality:
0.2 mL/kg: 1/5 after 7 days
1.6 mL/kg: no animal died
2.0 mL/kg: 1/5 after 7 days
2.5 mL/kg: 2/5 after 7 days
3.2 mL/kg: 4/5 after 7 days
6.4 mL/kg: all animals died within 7 days
Clinical signs:
other: Apathy, abdominal or lateral position, late mortalities.
Gross pathology:
questionable liver damage

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Remarks:
Migrated information
Conclusions:
The LD50 (male/female) was approximately 2675 mg/kg bw in rats.