Registration Dossier
Registration Dossier
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EC number: 218-491-7 | CAS number: 2163-00-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,6-dichlorohexane
- EC Number:
- 218-491-7
- EC Name:
- 1,6-dichlorohexane
- Cas Number:
- 2163-00-0
- Molecular formula:
- C6H12Cl2
- IUPAC Name:
- 1,6-dichlorohexane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bethesda-Black
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: watery emulsion with traganth
- Doses:
- 0.2, 1.6, 2.0, 2.5, 3.2 or 6.4 mL/kg (214, 1710, 2138, 2673, 3421 and 6842 mg/kg bw)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 675 mg/kg bw
- Remarks on result:
- other: original value: about 2.5 mL/kg bw
- Mortality:
- 0.2 mL/kg: 1/5 after 7 days
1.6 mL/kg: no animal died
2.0 mL/kg: 1/5 after 7 days
2.5 mL/kg: 2/5 after 7 days
3.2 mL/kg: 4/5 after 7 days
6.4 mL/kg: all animals died within 7 days - Clinical signs:
- other: Apathy, abdominal or lateral position, late mortalities.
- Gross pathology:
- questionable liver damage
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 (male/female) was approximately 2675 mg/kg bw in rats.
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