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Description of key information

No in vitro/vivo data are available for skin irritation/corrosion or eye irritation. However, based on the fact that this substance is a chlorosilane, so generates hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VII and VIII, Section 8.1 and 8.2, the in vitro/vivo skin irritation study and eye irritation study do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is a strong acid (pH ≤ 2.0) or base (pH ≥ 11.5) and the available information indicates that it should be classified as skin corrosion (Category 1, 1A, 1B or 1C)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Trichloro(hexadecyl)silane hydrolyses rapidly in contact with water and moist air, releasing three moles of hydrogen chloride (HCl) for one mole of parent molecule. Although no in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes.


Justification for classification or non-classification

Trichloro(hexadecyl)silane is classified as Skin Corr. 1A with hazard statement H314 ‘Causes severe skin burns and eye damage’ according to Regulation (EC) No. 1272/2008.


 


 


There are no experimental data for respiratory tract irritation, the additional hazard statement EUH071 ‘Corrosive to the respiratory tract' (1272/2008/EC) is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product HCl generated by chlorosilanes on contact with moisture.