2,2,2-trichloro-1-phenylethyl acetate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data for various test chemicals

Justification for type of information:

experimental data for various test chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE report is prepared based on toxicity to microorganisms study:
2, 3

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Vibrio fisheri

Test type:

static

Water media type:

other: 2nd and 3rd: Marine Water

Total exposure duration:

30 min

Remarks on exposure duration:

toxicity data to vibrio fisheri (the acute Microtox test) at each of the 5, 15 and 30-min endpoints.

Reference substance (positive control):

no

Key result

Duration:

35 min

Dose descriptor:

other: pT35

Remarks:

pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the 35 min

Effect conc.:

1.09 mmol/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: concentration required to elicit a 50% reduction in light emission

Remarks on result:

other: 2nd study

Duration:

30 min

Dose descriptor:

other: pT35

Remarks:

pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the 35 min

Effect conc.:

1.52 mmol/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: concentration required to elicit a 50% reduction in light emission

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

2nd: Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

3rd: Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.52.

Executive summary:

First study provide a means to predict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

First study was supported by second from peer reviewed journal, provide a means to predict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30, pT15 and pT5 was predicted to be 1.52, 1.59 and 1.66 respectively.

Description of key information

Study provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

Key value for chemical safety assessment

EC50 for microorganisms:

1.09 mg/L

Additional information

First study provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30 was predicted to be 1.09.

First study was supported by second from peer reviewed journal, provide a means topredict the ‘minimum’ toxicity that a phenol willexert in the Microtox test.Toxicity data noted as ‘pT’ are listed as the negative logarithm of the millimolar concentration required to elicit a 50% reduction in light emission in the stated time (i.e. 5-, 15, or 30-min) and pT 30, pT15 and pT5 was predicted to be 1.52, 1.59 and 1.66 respectively.