Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to OECD / EU guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
4-bromo-1,2-dichlorobenzene
EC Number:
242-160-6
EC Name:
4-bromo-1,2-dichlorobenzene
Cas Number:
18282-59-2
Molecular formula:
C6H3BrCl2
IUPAC Name:
4-bromo-1,2-dichlorobenzene

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.3
Temp.:
25 °C
pH:
7

Applicant's summary and conclusion

Conclusions:
The logarithmic partition coefficient (n-octanol/water) of the test item was determined to be log P9w = 4.3 at pH 7 using the HPLC method at 25 °C ± 1 °C.