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Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: 5 applications
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1974
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Principles of method if other than guideline:
On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
α,α,α-trifluoro-3-tolyl isocyanate
EC Number:
206-341-3
EC Name:
α,α,α-trifluoro-3-tolyl isocyanate
Cas Number:
329-01-1
Molecular formula:
C8H4F3NO
IUPAC Name:
1-isocyanato-3-(trifluoromethyl)benzene
Constituent 2
Reference substance name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
IUPAC Name:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
Details on test material:
Test substance: Hoechst substance 99.47% purity

Test animals

Species:
rabbit
Strain:
other: Russian White
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
5 times during 5 days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
100%, 10%, 5%, 1%
Basis:
other: concentration of applied test material
No. of animals per sex per dose:
6 animals per concentration
Control animals:
other: not required

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.

Applicant's summary and conclusion

Executive summary:

On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.