α,α,α-trifluoro-3-tolyl isocyanate

Repeated dose toxicity: dermal

Administrative data

Endpoint:

repeated dose toxicity: dermal

Remarks:

other: 5 applications

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: secondary literature

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Unnamed

Year:

1974

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Principles of method if other than guideline:

On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α-trifluoro-3-tolyl isocyanate

EC Number:

206-341-3

EC Name:

α,α,α-trifluoro-3-tolyl isocyanate

Cas Number:

329-01-1

Molecular formula:

C8H4F3NO

IUPAC Name:

1-isocyanato-3-(trifluoromethyl)benzene

Constituent 2

Reference substance name:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate

IUPAC Name:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate

Details on test material:

Test substance: Hoechst substance 99.47% purity

Test animals

Species:

rabbit

Strain:

other: Russian White

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

5 times during 5 days

Frequency of treatment:

once daily

Doses / concentrations

Remarks:

Doses / Concentrations:
100%, 10%, 5%, 1%
Basis:
other: concentration of applied test material

No. of animals per sex per dose:

6 animals per concentration

Control animals:

other: not required

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.

Applicant's summary and conclusion

Executive summary:

On the clipped and intact skin of 6 rabbits each, 0.5 ml of the test substance was applied 5 times once daily during 5 days undiluted and as a 10%, 5% or 1% solution.

Undiluted and as a 10% solution the test substance induced a pronounced redness with strong skin wrinkles and dryness of skin. A dilution of 5% revealed only for 24 hours a slight rednesson 3 animals. A dilution of 1% exhibited no relevant skin findings.