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EC number: 206-341-3 | CAS number: 329-01-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only abstract available; original reference in Russian
Data source
Reference
- Reference Type:
- publication
- Title:
- Data to substantiate of the maximum permissible level of m-trifluoromethylphenyl isocyanate and butyl isocyanate in the air of work areas
- Author:
- Gurova AI, Alekseeva NP, Gorlova OE, Chernyshova RA
- Year:
- 1 976
- Bibliographic source:
- Gig. Tr. Pro. Zabol 3, 53-55, cited from English abstract.
Materials and methods
- Principles of method if other than guideline:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³
- GLP compliance:
- not specified
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolyl isocyanate
- EC Number:
- 206-341-3
- EC Name:
- α,α,α-trifluoro-3-tolyl isocyanate
- Cas Number:
- 329-01-1
- Molecular formula:
- C8H4F3NO
- IUPAC Name:
- 1-isocyanato-3-(trifluoromethyl)benzene
- Reference substance name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- IUPAC Name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- Details on test material:
- Test substance: m-trifluormethylphenyl isocyanate, no data on purity
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- periodic (no furher data)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.3, 6.1 and 11.2 mg/m³
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: 3 months
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 11.2 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: functional and histological changes
- Remarks on result:
- other: functional and histological changes in lungs, liver, kidneys, heart, and brain
Target system / organ toxicity
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 11.2 mg/m³ air
- System:
- other: lungs, liver, kidneys, heart, and brain
- Organ:
- other: functional and histological changes in lungs, liver, kidneys, heart, and brain
- Treatment related:
- yes
- Dose response relationship:
- yes
Any other information on results incl. tables
At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain; at 1.3 mg/m³ the test substance is nontoxic for rats. All symptoms of poisoning disappeared within 3 months after the experiments are ceased.
Applicant's summary and conclusion
- Executive summary:
alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³.
At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain;
at 1.3 mg/m³ the test substance is nontoxic for rats and mice. All symptoms of poisoning disappear within 3 months after the experiments are ceased.
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