α,α,α-trifluoro-3-tolyl isocyanate

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: only abstract available; original reference in Russian

Data source

Reference

Reference Type:

publication

Title:

Data to substantiate of the maximum permissible level of m-trifluoromethylphenyl isocyanate and butyl isocyanate in the air of work areas

Author:

Gurova AI, Alekseeva NP, Gorlova OE, Chernyshova RA

Year:

1976

Bibliographic source:

Gig. Tr. Pro. Zabol 3, 53-55, cited from English abstract.

Materials and methods

Principles of method if other than guideline:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α-trifluoro-3-tolyl isocyanate

EC Number:

206-341-3

EC Name:

α,α,α-trifluoro-3-tolyl isocyanate

Cas Number:

329-01-1

Molecular formula:

C8H4F3NO

IUPAC Name:

1-isocyanato-3-(trifluoromethyl)benzene

Constituent 2

Reference substance name:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate

IUPAC Name:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate

Details on test material:

Test substance: m-trifluormethylphenyl isocyanate, no data on purity

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

air

Remarks on MMAD:

MMAD / GSD: no data

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

4 months

Frequency of treatment:

periodic (no furher data)

Doses / concentrations

Remarks:

Doses / Concentrations:
1.3, 6.1 and 11.2 mg/m³
Basis:
no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Details on study design:

Post-exposure period: 3 months

Results and discussion

Results of examinations

Clinical signs:

not specified

Mortality:

not specified

Body weight and weight changes:

not specified

Food consumption and compound intake (if feeding study):

not specified

Food efficiency:

not specified

Water consumption and compound intake (if drinking water study):

not specified

Ophthalmological findings:

not specified

Haematological findings:

not specified

Clinical biochemistry findings:

not specified

Urinalysis findings:

not specified

Behaviour (functional findings):

not specified

Organ weight findings including organ / body weight ratios:

not specified

Gross pathological findings:

not specified

Histopathological findings: non-neoplastic:

effects observed, treatment-related

Histopathological findings: neoplastic:

not specified

Effect levels

Dose descriptor:

LOAEL

Effect level:

11.2 mg/m³ air

Based on:

test mat.

Sex:

not specified

Basis for effect level:

other: functional and histological changes 

Remarks on result:

other: functional and histological  changes in lungs, liver, kidneys, heart, and brain

Target system / organ toxicity

Critical effects observed:

yes

Lowest effective dose / conc.:

11.2 mg/m³ air

System:

other: lungs, liver, kidneys, heart, and brain

Organ:

other: functional and histological  changes in lungs, liver, kidneys, heart, and brain

Treatment related:

yes

Dose response relationship:

yes

Any other information on results incl. tables

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain; at 1.3 mg/m³ the test substance is nontoxic for rats. All symptoms of poisoning disappeared within 3 months after the experiments are ceased.

Applicant's summary and conclusion

Executive summary:

alpha,alpha,alpha-trifluoro-3-tolyl isocyanate was studied on rats which were kept for 4 month with periodic introduction of alpha,alpha,alpha-trifluoro-3-tolyl isocyanate into the air in exptl. chambers in concentrations of of 1.3, 6.1, and 11.2 mg/m³.

At 11.2 mg/m³ the test substance causes functional and histological changes in lungs, liver kidneys, heart, and brain;

at 1.3 mg/m³ the test substance is nontoxic for rats and mice. All symptoms of poisoning disappear within 3 months after the experiments are ceased.