Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-341-3 | CAS number: 329-01-1
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Title:
- No information
- Author:
- GUROVA AI, ALEKSEEVA NP, GORLOVA OE, CHERNYSHOVA RA (1976)|Gig Tr Prof Zabol, 3, 53-55 (Russian)
Materials and methods
- Principles of method if other than guideline:
- The test substance was applied by repeated introduction in stomach for 22, 45, or 90 days. Animals were observed for mortality and clinical signs.
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α,α-trifluoro-3-tolyl isocyanate
- EC Number:
- 206-341-3
- EC Name:
- α,α,α-trifluoro-3-tolyl isocyanate
- Cas Number:
- 329-01-1
- Molecular formula:
- C8H4F3NO
- IUPAC Name:
- 1-isocyanato-3-(trifluoromethyl)benzene
- Reference substance name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- IUPAC Name:
- alpha,alpha,alpha-trifluoro-3-tolyl isocyanate
- Details on test material:
- Test substance: no data
Constituent 1
Constituent 2
Test animals
- Species:
- other: rodent
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 22, or 45, or 90 days
- Frequency of treatment:
- no details reported
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 200, 100, and 50 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
repeated introduction in stomach in doses of 1/5, 1/10, and 1/20 LD50 (total cumulative dose= 4.5 times LD50; LD50= 975
mg/kg in rat and mouse) did not provoke the death of animals; increasing excitement, body weight loss,
respiratory effects
Applicant's summary and conclusion
- Executive summary:
The test substance was applied by repeated introduction in stomach for 22, 45, or 90 days. Animals were observed for mortality and clinical signs.
Doses of 1/5, 1/10, and 1/20 LD50 (total cumulative dose= 4.5 times LD50; LD50= 975 mg/kg bw in rats and mouse). These doses did not provoke the death of animals; an increasing excitement, body weight loss, and respiratory effects were found.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
