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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In a limit test with 2000 mg test substance/kg bw according to OECD TG 401 and GLP no mortalities have been observed.
LD50, rat, oral: >2000 mg/kg bw

Key value for chemical safety assessment

Additional information

Acute, oral:

In an acute toxicity study with 5 male and 5 female Tif: RAI f (SPF) rats, the animals were dosed with a limit dose of 2000 mg/kg bw by gavage. The study was conducted according to OECD TG 401 (adopted 1987) and GLP regulations. The animals were checked for mortality and signs and symptoms. Body weights were determined on day 0, 7, and 14 and a gross necropsy was performed at the end of the 14 day observation period.

In both sexes piloerection, hunched posture and dyspnea were observed, but were reversible within 4 -6 days after administration. No mortalities occurred and no findings after necropsy were reported. Thus, an LD50 of >2000 mg/kg bw was deduced.

Acut, inhalation:

No data available.

Acut, dermal:

No data available.

Justification for classification or non-classification

Dangerous Substance Directive (67/548/EEC)

-No classification required for acute toxicity

Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):

- Oral route: no classification required