Registration Dossier
Registration Dossier
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EC number: 272-940-1 | CAS number: 68921-45-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not conducted in compliance with GLP and test standard not referenced within the report, however data included for OECD SIDS dossier data.
Data source
Reference
- Reference Type:
- other: SIDS Dossier data
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Not specified
- Principles of method if other than guideline:
- Method not specified; however given the age of the study, a standard acute method is most appropriate.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 68442-68-2
- Cas Number:
- 68442-68-2
- IUPAC Name:
- 68442-68-2
- Test material form:
- liquid: viscous
- Details on test material:
- CAS No: 68442-68-2
EINECS No: 270-485-3
EINECS Name: Benzenamine, N-phenyl-, styrenated
CAS Name: Benzenamine, N-phenyl-, styrenated
Substance type: organic
Physical status: liquid
Purity: > 98 % w/w
Result: Molecular weight: 320
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Remarks:
- 25%
- Details on oral exposure:
- The material was placed in a 25% corn oil solution.
- Doses:
- 2500, 5000, 10000, 20000, and 40000 mg/kg
- No. of animals per sex per dose:
- Five rats per dose.
- Control animals:
- no
- Details on study design:
- The animals were observed for 14 days.
- Statistics:
- Not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Two of the five animals died at the dosages of 20000 and 40000 mg/kg.
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 20000 mg/kg bw
- Executive summary:
Study not conducted in compliance with GLP and test standard not referenced within the report, however data included for OECD SIDS dossier. LD50 > 20000 mg/kg bw. Read across to supporting substance, CAS No. 68442 -68 -2, by structural analogue.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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