Registration Dossier
Registration Dossier
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EC number: 248-885-4 | CAS number: 28178-42-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,6-diisopropylphenyl isocyanate
- EC Number:
- 248-885-4
- EC Name:
- 2,6-diisopropylphenyl isocyanate
- Cas Number:
- 28178-42-9
- Molecular formula:
- C13H17NO
- IUPAC Name:
- 2-isocyanato-1,3-bis(propan-2-yl)benzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
Results and discussion
Any other information on results incl. tables
| irritating effect on the skin | |||||||||
| animal | body w. | 1 h | 24 h | 48 h | 72 h | 7 days | 14 days | irrit. index | |
| 1 | 3.5 kg | erythema | 2 | 2 | 2 | 2 | 2 | 3 | 2 |
| edema | 4 | 2 | 2 | 2 | 3 | 3 | 2 | ||
| 2 | 3.4 kg | erythema | 2 | 2 | 2 | 2 | 2 | 3 | 2 |
| edema | 3 | 2 | 2 | 2 | 3 | 3 | 2 | ||
| 3 | 3.4. kg | erythema | 2 | 2 | 2 | 2 | 2 | 4 | 2 |
| edema | 3 | 2 | 2 | 2 | 3 | 4 | 2 | ||
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Corrosive to skin according to CLP regulation.
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