Registration Dossier
Registration Dossier
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EC number: 248-885-4 | CAS number: 28178-42-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: database entry, trustful source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- No information
- Year:
- 2 008
- Bibliographic source:
- National Technical Information Service, Springfield 22161, Formerly U.S. Clearinghouse for Scientific and Technical Information OTS0530415
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,6-diisopropylphenyl isocyanate
- EC Number:
- 248-885-4
- EC Name:
- 2,6-diisopropylphenyl isocyanate
- Cas Number:
- 28178-42-9
- Molecular formula:
- C13H17NO
- IUPAC Name:
- 2-isocyanato-1,3-bis(propan-2-yl)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 414 mg/kg bw
- Based on:
- not specified
- Clinical signs:
- other: GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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