Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

Currently viewing:

Administrative data

Endpoint:
developmental toxicity
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please refer to the category justification provided in the category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C12-14 (even-numbered), ethoxylated, magnesium salts, < 2.5 mol EO
EC Number:
939-578-2
Molecular formula:
not applicable
IUPAC Name:
Alcohols, C12-14 (even-numbered), ethoxylated, magnesium salts, < 2.5 mol EO

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Key result
Dose descriptor:
NOAEL
Effect level:
300 mg/kg bw/day (actual dose received)
Based on:
test mat.
Basis for effect level:
other: Read-across based on all available data on reproductive / developmental toxicity in the Alkyl Ether Sulfates (AES) category.

Maternal abnormalities

Key result
Abnormalities:
no effects observed

Results (fetuses)

Effect levels (fetuses)

Key result
Dose descriptor:
NOAEL
Effect level:
300 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: Read-across based on all available data on reproductive / developmental toxicity in the Alkyl Ether Sulfates (AES) category.

Fetal abnormalities

Key result
Abnormalities:
no effects observed

Overall developmental toxicity

Key result
Developmental effects observed:
no

Any other information on results incl. tables

For a detailed assessment of the developmental toxicity of the Alkyl Ether Sulfates (AES) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Conclusions:
Applying read-across based on grouping of substances (category approach), no toxicologically relevant effects in relation to developmental toxicity and a NOAEL for developmental toxicity of 300 mg/kg bw/day are predicted for the target substance.
Executive summary:

The available data on developmental toxicity in the Alkyl Ether Sulfates (AES) category indicate no toxicologically relevant effects for the target substance. As explained in the category justification, the differences in molecular structure and composition between the target substance and the members of the AES category are unlikely to lead to differences with respect to developmental toxicity.