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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please refer to the category justification provided in the category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C12-14 (even-numbered), ethoxylated, magnesium salts, < 2.5 mol EO
EC Number:
939-578-2
Molecular formula:
not applicable
IUPAC Name:
Alcohols, C12-14 (even-numbered), ethoxylated, magnesium salts, < 2.5 mol EO

Results and discussion

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
300 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: Read-across based on all available data on repeated dose toxicity in the Alkyl Ether Sulfates (AES) category.

Target system / organ toxicity

Key result
Critical effects observed:
no

Any other information on results incl. tables

For a detailed assessment of the repeated dose toxicity of the Alkyl Ether Sulfates (AES) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Conclusions:
Applying read-across based on grouping of substances (category approach), no toxicologically relevant effects after subacute repeated dose administration and a NOAEL for systemic toxicity of 300 mg/kg bw/day are predicted for the target substance.
Executive summary:

The available data on repeated dose toxicity in the Alkyl Ether Sulfates (AES) category indicate no toxicologically relevant effects for the target substance. As explained in the category justification, the differences in molecular structure and composition between the target substance and the members of the AES category are unlikely to lead to differences with respect to subacute repeated dose toxicity.