Registration Dossier
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EC number: 229-222-8 | CAS number: 6440-58-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Reliable (Klimisch 1) toxicity studies with algae have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Vryenhoef & Mullee (2007) provides an estimated 72hr EC50 of 11 mg/L and 72hr NOEC of 5.1 mg/L, based on growth using DMDMH. Consequently this value will be taken as the toxicity in algae endpoint for DMDMH.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 11 mg/L
- EC10 or NOEC for freshwater algae:
- 5.1 mg/L
Additional information
Reliable (Klimisch 1 or 2) toxicity studies with algae have been conducted for DMDMH or the hydrolysis product of DMDMH, DMH and are included in this dossier. DMDMH readily undergoes hydrolysis to DMH and therefore data are provided for both substances when available. In the case of long-term testing, the data on DMH is considered more relevant for environmental fate and ecotoxicology and are considered in this dossier.
Vryenhoef & Mullee (2007) conducted a reliable (Klimisch 1) GLP compliant study following OECD 201 methods. The algae, Desmodesmus subspicatus, were exposed to measured concentrations (nominal; 1.0, 3.2, 10, 32 and 100 mg/L) of DMDMH in a static system for 72 hours. The 72hr EC50, EC10 and NOEC, based on growth, was 11 mg/L, 5.7 mg/L and 5.1 mg/L, respectively.
Vryenhoef & Hill (2006) conducted a reliable (Klimisch 1) GLP compliant study following OECD 201 methods. The algae, Pseudokirchneriella subcapitata, were exposed to a measured concentration (1000 mg/L) of DMH, the hydrolysis product of DMDMH in a static system for 96 hours. The 96hr EC50, based on growth, was >1000 mg/L and the NOEC was 1000 mg/L.
Reliable (Klimisch 1) toxicity studies with algae have been conducted for DMDMH and DMH, the hydrolysis product of DMDMH and are included in this dossier. The study Vryenhoef & Mullee (2007) provides an estimated 72hr EC50 of 11 mg/L and 72hr NOEC of 5.1 mg/L, based on growth using DMDMH. Consequently this value will be taken as the toxicity in algae endpoint for DMDMH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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