Registration Dossier
Registration Dossier
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EC number: 203-797-5 | CAS number: 110-73-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A review of avaialable data is available for the structurally-related read-across substance 2-diethylaminoethanol.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Studies investigating the toxicokinetics of the structurally-related read-across substance 2 -diethylaminoethanol are summarised in an OECD SIDS evaluation. Data indicate rapid oral absorption and extensive systemic distribution. The major rat metabolites were identified as diethylaminoacetic acid and diethyl-(2-hydroxyethyl)-amino-oxide; excretion was primarily via the urine. there is some evidence for metabolic incorporation into phospholipids; however the rapid metabolism excretion suggests that true bioaccumulation is unlikely. Default absorption values are used for the purposes of risk assessment.
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