Registration Dossier
Registration Dossier
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EC number: 203-797-5 | CAS number: 110-73-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A 21-day reproduction test was conducted to determine the toxicity of 2-(Ethylamino)ethanol on Daphnia magna, in accordance with the OECD
Chemicals Testing Guideline No.211 Daphnia magna Reproduction Test (adopted 3 October 2008).
For the definitive test the nominal 2-(Ethylamino)ethanol concentration range was 0.512, 1.28, 3.2, 8.0, 20 and 50 mg/L. A control group
(ASTM only) was also prepared. The concentration range was based on the results of a range-finding test (conducted at nominal
2-(ethylamino)ethanol concentrations of 0.01, 0.10, 1.0, 10 and 100 mg/L), which is not reported. The test was conducted as a semi-static design with a three times weekly renewal of test media.
The overall mean measured concentrations of 2-(Ethylamino)ethanol in samples of test media were 0.585, 1.35, 3.11, 7.55, 21.0 and 49.1 mg/L,
corresponding to 114, 105, 97.1, 94.4, 105 and 98.3% of the nominal concentrations and therefore toxicity results have been based on nominal
concentrations.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.2 mg/L
Additional information
A 21-day Daphnia magna reproduction study was conducted to determine the effects of 2-(ethylamino)ethanol on Daphnia magna reproduction and survival according to OECD 211
The Day 21 EC50, NOEC and LOEC toxicity values in terms of juveniles produced per surviving parental Daphnia magna were calculated to be >3.2, 3.2 and 8.0 mg/L respectively.
The Day 21 EC50, NOEC and LOEC toxicity values for carapace lengths of surviving parental Daphnia magna were calculated to be >3.2, 3.2 and 8.0 mg/L respectively.
The validity criteria were satisfied, and therefore the results of the reproduction test are considered to be valid.
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