Registration Dossier
Registration Dossier
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EC number: 200-157-7 | CAS number: 52-89-1
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.083 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.83 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.008 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 18 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
In accordance with article 2(7)(b) and Annex V 6., REACH the hydrate free form of L-Cysteine hydrochloride is registered. L-Cysteine hydrochloride monohydrate (CAS 7048-04-6, hydrate part of the molecule = 10.25 %) is the manufactured and imported substance and was therefore in many cases used for testing.
It is generally accepted that water and especially water of crystallisation has no toxicologically relevant effects. Therefore, the effect levels of L-Cysteine hydrochloride monohydrate can be used to calculate the corresponding dosages of L-Cysteine hydrochloride (anhydrous (free of water of crystallisation)).
Thus, the conclusion on hazard assessment and classification holds true for the anhydrous form as well.
For L-Cysteine hydrochloride as well as for the monohydrate form: no classification according to the criteria laid out in regulation (EC) 1272/2008 (CLP). This is justified as follows.
available for classification relevant ecotoxictity/ environmental fate data:
- EC50 (fish (96 h)) > 100 mg/L
- EC50 (daphnia (48 h)) > 100 mg/L
- ErC50/ ErC10 algae (72 h) = 83/ 22 mg/L.
- readily biodegradable
The lowest effect concentrations are in the range of 10 to 100 mg/L and the substance is readily biodegradable. Therefore, L-Cysteine hydrochloride as well as L-Cysteine hydrochloride monohydrate do not need to be classified as hazardous to the aquatic environment according to the criteria of table 4.1.0 of CLP-regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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