Registration Dossier
Registration Dossier
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EC number: 240-178-9 | CAS number: 16039-53-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see "details on method"
- Principles of method if other than guideline:
- Refer S
- GLP compliance:
- not specified
- Type of method:
- other: Similar to flask method
- Specific details on test material used for the study:
- L(+) zinc lactate (Zn-CH3CHOHCOO)2·H2O) was of analytical grade and purchased from Sigma Chemical Co.
- Key result
- Water solubility:
- 48.2 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 7
- Details on results:
- The solubilities of L(+) and DL(±) zinc lactate in water at a temperature range between 5 and 80 °C. L(+) zinc lactate showed higher solubility than DL(±) zinc lactate. At 10 °C, the solubility of L(+) zinc lactate was 4.22 % while it was 12.16 % at 80 °C. When the temperature increased from 5 to 65 °C, the solubility increased slowly with temperature. However, it increased rapidly at a temperature between 65 and 80 °C. DL(±) zinc lactate showed lower solubility than L(+) zinc lactate. At 10 °C, the solubility of DL (±) zinc lactate was only 1.21 % and it was 6.6 2% at 80 °C.
The following regression equation was derived for L(+)zinc lactate:
Solubility (g anhydrate/100g solution)= 3.7 + 0.0412T + 0.0013T² - 3.56E-5T³ + 3.78E-7T^4,
with T = temperature (5-80°C) - Conclusions:
- The water solubilty of zinc lactate is calculated to be 48.2 g/L at 20°C.
- Executive summary:
The water solubility of zinc-lactate was determined in a study similar to the flask method according to EU method A.6 (Regulation EC 440/2008). Various concentrations of calcium lactate and zinc lactate suspensions were prepared and stirred for 2 to 4 hours until they reached an equilibrium at a given temperature.Tested temperature range was between 5 and 80 °C. Conductivity of each sample was measured and solubility was determined against a conductivity-solubility calibration curve. The results indicate an overall solubility in water of 48.2 g/L at 20 °C.
Reference
Description of key information
The water solubility of zinc lactate is calculated to be 48.2 g/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 48.2 g/L
- at the temperature of:
- 20 °C
Additional information
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