Registration Dossier
Registration Dossier
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EC number: 244-499-5 | CAS number: 21651-19-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: subacute and subchronic
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study, only form secondary literature, source: US OSHA
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Occupational Safety and Health Guideline for Tin Oxide
- Author:
- US OSHA
- Year:
- 1 994
- Bibliographic source:
- http://www.osha.gov/SLTC/healthguidelines/tinoxide/recognition.html
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- guideline unknown
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tin monoxide
- EC Number:
- 244-499-5
- EC Name:
- Tin monoxide
- Cas Number:
- 21651-19-4
- Molecular formula:
- OSn
- IUPAC Name:
- Tin monoxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 and 13 wks
- Frequency of treatment:
- daily with food
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.03
Basis:
other: percent of feed
- Remarks:
- Doses / Concentrations:
0.1
Basis:
other: percent of feed
- Remarks:
- Doses / Concentrations:
0.3
Basis:
other: percent of feed
- Remarks:
- Doses / Concentrations:
1.0
Basis:
other: percent of feed
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent no treatment
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No adverse effects following 4 and 13 weeks of exposure, toxicity criteria used in the study included body weight change, diet utilization, organ weights, mortality, and blood, urine, or biochemical parameter changes
Applicant's summary and conclusion
- Conclusions:
- No adverse effects following 4 and 13 weeks of exposure, toxicity criteria used in the study included body weight change, diet utilization, organ weights, mortality, and blood, urine, or biochemical parameter changes, highst dose: 1 % in feed
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