Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: study before guideline and glp time
Data waiving:
other justification
Justification for data waiving:
other:
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
yes
Remarks:
dose selection
Principles of method if other than guideline:
study from 1975, comparable with OECD 423; dose selection see point doses
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male
Route of administration:
oral: gavage
Vehicle:
water
Doses:
fasted (no food 16-18hrs before application): 600, 1200, 1800, 2400, 4800 mg/kg bw
feed: 1500, 1800, 3000, 6000 mg / kg /bw
No. of animals per sex per dose:
10
Control animals:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 2 274.6 mg/kg bw
Based on:
other: SnCl_2 * H2O
95% CL:
> 1 613.2 - < 3 207.2
Remarks on result:
other: fasted rats
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3 190.1 mg/kg bw
Based on:
other: SnCl_2 *H2O
95% CL:
> 2 044.9 - < 4 976.6
Remarks on result:
other: feeded tats
Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for stannous dichloride dihydrate was determined to be 2274.6 mg/kg bw. Form this value the LD50 for stannous chloride form 1910.1 mg/kg bw was calculated.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 392 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification