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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7 Aug 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
No analytical measurement, but visual inspection of the solution. Reason: completely miscible in all concentrations and gelling for concentration > 400 g/L.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
No analytical measurement, but visual inspection of the solution. Reason: completely miscible in all concentrations and gelling for concentration > 400 g/L.
GLP compliance:
no
Type of method:
flask method
Water solubility:
> 400 g/L
Temp.:
20 °C
pH:
10.04

Preliminary test:

In a preliminary test, the following aliquots were added to 10 g of water and stirred slowly for 10 minutes:

Aliquot

Weighed sample, g

A

1.23

B

2.75

C

2.87

Sum

6.85

While being added to the water, solutions with increasing viscosity were being formed, resulting in a gel after the addition of 6.85 g of the test item.

With 6.85 g of test item being mixed into 10 g of water, a gel with a total weight of 16.85 g has been formed. This is equivalent to 41% (w/w) of test item in solution/gel.

As the water density will significantly increase with addition of the test item, it can be concluded that water solubility is about 410 g/L, resulting in a gel. Due to the fact that the formation of the gel is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility can be approximated to > 400 g/L.

Conclusions:
Interpretation of results: miscible

Description of key information

> 400 g/L at 20 °C, pH = 10.04

Key value for chemical safety assessment

Additional information

The water solubility of the substance was determined according to EU Method A.6 and OECD 105 (flask method). Gel formation was observed at concentrations > 400 g/L.