Registration Dossier
Registration Dossier
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EC number: 500-465-4 | CAS number: 160901-28-0 1 - 2.5 moles ethoxylated
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Nov 2012 - 10 Jan 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EU test method L383 A/54-62 (EEC A.6)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Principles of method if other than guideline:
- Similar experimental conditions applied as required for water solubility determinantion according to guidelines listed above.
- GLP compliance:
- no
- Medium:
- n-octanol
- Solubility:
- 55.43 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value as mentioned in the guidelines cannot be indicated because it is defined for aqueous and not octanol solutions.
- Test substance stable:
- yes
Reference
Study results:
Incubation time, h |
Weighted sample, g |
Concentration, g/L |
24 |
1.5074 |
54.55 |
48 |
1.5095 |
55.70 |
72 |
1.5032 |
56.05 |
A concentration plateau could be reached over 72 hours at 30 °C with 24 hours subsequent incubation at 20 °C.
Total average concentration over three incubation times was 55.43 g/L, RSD 1.4%.
Description of key information
n-octanol solubility: 55.43 g/L at 20 °C
Key value for chemical safety assessment
Additional information
The solubility of the substance in n-octanol was determined applying similar experimental conditions as described for determination of water solubility according to EU method A.6 and OECD 105 (flask method).
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