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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The conduct of the inhalation hazard test was similar to the IHT as reported in Annexe V of the OECD TG 403 (1981).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
(adopted on 1981, 12th May; inhalation hazard test)
Deviations:
yes
Remarks:
(BASF test, animals were observed for only 7 days, no details only animal husbandry, exposure period of up to 8 hours, concentration of test substance in air mixture was not verified analytically)
GLP compliance:
no
Test type:
other: inhalation hazard test (IHT)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-dibutylaminoethanol
EC Number:
203-057-1
EC Name:
2-dibutylaminoethanol
Cas Number:
102-81-8
Molecular formula:
C10H23NO
IUPAC Name:
2-(dibutylamino)ethan-1-ol
Details on test material:
- Name of test material (as cited in study report): Dibutylaethanolamin
- Analytical purity: >99%

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 225 g (mean)
No further data.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
BASF Test:
The test demonstrates the toxicity of an atmosphere saturated with vapours of the test substance at the temperature chosen for vapour generation (20°C). 6 rats per sex were exposed consecutively to the vapours, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
0.15 mg/L
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: Inhalation Hazard Test
Effect level:
0.15 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: No death occurred.
Mortality:
No death occurred.
Clinical signs:
other: None.
Body weight:
No data on body weight gain.
Gross pathology:
No abnormalities were observed.

Applicant's summary and conclusion