Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-057-1 | CAS number: 102-81-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Method is not validated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin Notation in the Context of Workplace Exposure Standards
- Author:
- Scansetti G, Pialatto G, Rubino GF
- Year:
- 1 988
- Bibliographic source:
- American Journal of Industrial Medicine 14: 725-732
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In this publication, the "skin notation" of a battery of substances was given. The "skin notation" is defined as a ‘liquid compound that can penetrate the unbroken skin to cause systemic effects’. Dermal lethal dose to 50% (LD50) or human data are the bases for the assignment of "skin notation" to 91 of 168 substances.
Test material
- Reference substance name:
- 2-dibutylaminoethanol
- EC Number:
- 203-057-1
- EC Name:
- 2-dibutylaminoethanol
- Cas Number:
- 102-81-8
- Molecular formula:
- C10H23NO
- IUPAC Name:
- 2-(dibutylamino)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dibutylaminoethanol
No further data available.
Constituent 1
Results and discussion
Any other information on results incl. tables
For the test substance, a dose of 2 g/kg was reported as the "cut-off" value of the dermal LD50 for skin notation attribution. This is also the value in the EEC (European Economic Community) classification of dermal biological hazards as the upper limit of "harmful category" i .e ., substances involving "limited health risks".
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
