Fatty acids, C16-18, barium salts

Endpoint summary

Additional information

Introduction

A comprehensive data gap analysis was conducted for the entire substance portfolio of the Metal carboxylates REACH Consortium (MCRC), covering 10 metal carboxylates in total. This literature screening effort included:

 

• all available proprietary studies from the Metal carboxylates REACH Consortium (MCRC)
• detailed literature searches in online databases
• screening of human health review articles
• rigorous quality and reliability screening according to Klimisch criteria, where those criteria apply

 

During the literature search and data gap analysis it became obvious that the overall database on substance-specific human health hazard data for the metal carboxylates is too scant to cover all REACH endpoints. Therefore, the remaining data gaps had to be covered by either experimental testing or read-across from similar substances.

 

Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the organic acid counterion and the metal (or one of its readily soluble salts). This way forward is acceptable, since metal carboxylates dissociate to the organic anion and the metal cation upon dissolution in aqueous media. No indications of complexation or masking of the metal ion through the organic acid were apparent during the water solubility tests (please refer to the water solubility data in section of the IUCLID and chapter of the CSR). Once the individual constituents of the metal carboxylate become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated metal carboxylate can be described by the toxicity of the “individual” constituents. Since synergistic effects are not expected for this group of metal carboxylates, the human health hazard assessment consists of an individual assessment of the metal cation and the organic anion.

 

The hazard information of the individual constituents was obtained from existing REACH registration dossiers via a license-to-use obtained by the lead registrant. These registration dossiers were submitted to ECHA in 2010 as full registration dossiers, and are thus considered to contain relevant and reliable information for all human health endpoints. All lead-registrant dossiers were checked for completeness and accepted by ECHA, i.e. a registration number was assigned.

 

Fatty acids, C16-18, barium salts is the barium metal salt of fatty acids, C16-18, which readily dissociates to the corresponding metal barium cation and fatty acids,C16-18, anions. The barium cation and the fatty acids, C16-18 anion are considered to represent the overall toxicity of fatty acids, C16-18, barium salts in a manner proportionate to the free acid and the metal (represented by one of its readily soluble salts). Based on the above information, unrestricted read-across is considered feasible and justified.

 

Although the term „constituent“ within the REACH context is defined as substance (also being part of a mixture), the term constituent within this hazard assessment is meant to describe either part of the metal carboxylate salt, i.e. anion or cation.

Genetic toxicity

No genetic toxicity study with fatty acids, C16-18, barium salts is available, thus the genetic toxicity will be addressed with existing data on the dissociation products as detailed in the table below.

 

Table: Summary of genetic toxicity data of fatty acids, C16-18, barium salts and the individual constituents.

	BaCl2 (CAS# 10361-37-2)	Fatty acids C16-C18 (CAS# 67701-03-5)	Fatty acids, C16-18, barium salts (CAS# 91002-07-2)
In vitro gene mutation in bacteria	Negative	Negative	Negative (read-across)
In vitro cytogenicity in mammalian cells or in vitro micronucleustest	Negative		Negative (read-across)
In vitro gene mutation study in mammalian cells	Negative		Negative (read-across)

 

Fatty acids, C16-18, barium salts is not expected to be genotoxic, since the two constituents barium and fatty acids, C16-18 have not shown genotoxic potential in a range of in vitro test systems. Thus, fatty acids, C16-18, barium salts is not to be classified according to regulation (EC) 1272/2008 as genetic toxicant. Further testing is not required. For further information on the toxicity of the individual constituents, please refer to the relevant sections in the IUCLID and CSR.

Justification for selection of genetic toxicity endpoint
Read-across information

Short description of key information:
Fatty acids, C16-18, barium salts is not expected to be genotoxic.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Fatty acids, C16-18, barium salts is not expected to be genotoxic, since the two constituents barium and fatty acids, C16-18 have not shown genotoxic potential in a range of in vitro test systems. Thus, fatty acids, C16-18, barium salts is not to be classified according to regulation (EC) 1272/2008 as genetic toxicant. Furthermore, fatty acids, C16-18, barium salts has not to be classified according to Directive 67/548 EC asgenetic toxicant.