Registration Dossier
Registration Dossier
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EC number: 237-486-0 | CAS number: 13814-96-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: secondary information made available in a report of "Berufsgenossenschaft der chemischen Industrie", 2000
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Tetrafluoroboric acid and its salts - Toxicological evaluation
- Author:
- Anonymous
- Year:
- 2 000
- Bibliographic source:
- BG Chemie InfoCenter Toxikologische Bewertungen (www.bgchemie.de)
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrafluoroboric acid
- EC Number:
- 240-898-3
- EC Name:
- Tetrafluoroboric acid
- Cas Number:
- 16872-11-0
- Molecular formula:
- BF4.H
- IUPAC Name:
- tetrafluoroborate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- A 51.5% aqueous solution of tetrafluoroboric acid was used for testing
- Doses:
- 10, 100, 464 and 1000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 464 - <= 1 000 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: The doses refers to 51.5% of an aqueous tetrafluoroboric acid solution
- Mortality:
- The signs of toxicity were reversible after 24 hours
- Clinical signs:
- other: The 10 mg/kg body weight dose was tolerated without signs of toxicity. Following 100 mg/kg body weight, dyspnoea, sedation and lack of appetite were observed, and in the males, half-closed eyes. The signs of toxicity were reversible after 24 hours. Follow
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information 51.5 % aqueous solution of tetrafluoroboric acid Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of 51-percent tetrafluoroboric acid was between 464 and 1000 mg/kg body weight and therefore, harmful if swallowed.
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