Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

minor deviations to study plan and guideline reagrding temperature of the study (20 °C ± 3 °C)

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

< 10 µg/L

Temp.:

20 °C

pH:

6.6

Details on results:

The water solubility of the test item was estimated using the column elution method. The saturation mass concentration of the test item was determined using a LC-MS/MSC method.

Results for the Determination of the Water Solubility of the Test Item            

sample description		concentration found	Dilution factor	concentration calculated	measured pH^2after Incubation
time [h]		[µg/L]		[µg/L]^1
flow rate 0.4 mL/min
48684185	0	4.086	2	8.172	6.6
48684185	1	7.116	2	14.233	6.6
48684185	2	-0.190	2	-0.379	6.7
48684185	3	0.325	2	0.650	6.7
48684185	4	1.289	2	2.578	6.7
48684185	5	-0.409	2	-0.818	6.8

mean value (n=4):            0.508

SD (n=4):            1.511

 

flow rate 0.2 mL/min
sample description		concentration found	Dilution factor	concentration calculated	measured pH^2after Incubation
time [h]		[µg/L]		[µg/L]^1
48684185	0	5.619	2	11.239	6.5
48684185	1	7.993	2	15.986	6.5
48684185	2	1.698	2	3.396	6.5
48684185	3	-0.361	2	-0.723	6.4
48684185	4	1.713	2	3.425	6.5
48684185	5	1.315	2	2.629	6.6

mean value (n=4):             2.182

SD (n=4):             1.971

 

 

 

1 rounded value calculated from regression data

2 measured with pH electrode

italic value excludedfrom mean value

Conclusions:

Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
Tetrabenzyl thiuram disulfid is insoluble in water

Executive summary:

The purpose of the study was to estimate the solubility of the test item in water which is specified by the saturation mass concentration of the test item in water at a specified temperature, according to the OECD 105 guideline.

The water solubility of the test item was estimated to be smaller than 0.01 g/L in a preliminary test (non-GLP). Therefore, the column elution method was used in the main test. The water solubility of the test item Tetrabenzyl thiuram disulfid (TBzTD) was determined to be below 10 µg/L using the column elution method for the performance of the main test.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

Information from migrated NONS file, as per inquiry number 06-2119987039-24-0000 ,permission to refer granted by ECHA

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes

Type of method:

other: inquiry # [06-0000014692-69-00000], permission to refer granted by ECHA: method is unknow

Water solubility:

<= 0.01 mg/L

Temp.:

21 °C

Remarks on result:

other: Information from migrated NONS file, as per inquiry number 06-2119987039-24-0000 ,permission to refer granted by ECHA

Conclusions:

Water solubility of TBzTD accordong to OECD 105 study is less than 10µg/L at 21°C.

Executive summary:

Water solubility of TBzTD accordong to OECD 105 study is less than 10µg/L at 21°C.

Description of key information

Two reliable studies performed according to OECD 105 guideline are available.

Both studies indicate a low water solubility (< 10µg/L).

For one of the two studies, information from migrated NONS file as per inquiry # [06-0000014692-69-00000], permission to refer granted by ECHA

 

Key value for chemical safety assessment

Water solubility:

0.01 mg/L

at the temperature of:

21 °C

Additional information

The purpose of the studies was to estimate the solubility of the test item in water which is specified by the saturation mass concentration of the test item in water at a specified temperature, according to the OECD 105 guideline.

 

The water solubility of the test item was estimated to be smaller than 0.01 g/L in a preliminary test (non-GLP). Therefore, the column elution method was used in the main test. The water solubility of the test item Tetrabenzyl thiuram disulfid (TBzTD) was determined to be below 10 µg/L using the column elution method.