Registration Dossier
Registration Dossier
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EC number: 222-023-7 | CAS number: 3320-83-0
Endpoint summary
Administrative data
Description of key information
The test substance causes burns to skin (labeling requirements: R34) (Leuschner, 1996).
No Eye irritation study available.
Key value for chemical safety assessment
Additional information
In a skin irritation study according OECD Guideline 404 3 male rabbits were exposed for 4 hours to 0.5 ml test substance/ patch and animal under semi-occlusive conditions. The first 60 minutes no effects were observed in all animals.
Beginning at 24hours up to 10 days erythema were observed in all animals. In addition, in all 3 rabbits moderate necrosis was observed 24 hours to 5 days and slight necrosis 6 days to 10 days after patch removal. The rabbit skin showed lacerations 8 to 10 days after patch removal, peeling and new skin at the 11th day and new skin from 12 to 14 days after patch removal.
There were no systemic intolerance reactions.
The test substance causes burns to skin (labeling requirements: R34) (Leuschner, 1996).
Justification for classification or non-classification
The test substance causes burns to skin (labeling requirements: R34).
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