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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acut oral: LD50 rat; male/female > 2000 mg/kg bw (Andrews, 1996);
Acut inhalation: LC 50 rat; male/ female 47 mg/m³ (Pauluhn, 1996);
Acut dermal: no data.

Key value for chemical safety assessment

Additional information

A study of acute oral toxicity in male and female Wistar rats was conducted with the test substance.

Following doses were tested by gavage: 200, 2000 mg/kg bw.

A dose of 200 mg/kg body weight was tolerated by male and female rats without signs and without mortalities. Clinical signs observed at 2000 mg/kg body weight consisted of piloerection, decreased motility and reactivity,uncoordinated and spastic gait, tachypnea, labored breathing, breathing sounds, diarrhea, and narrowed palpebral fissure, occurred within 1 hour and 2 days after administration, and usually lasted until 7 hours to 3 days. Body weight and body weight gain were not affected by treatment.

General autolysis was observed in animals that died during the observation period. The gross pathology investigations performed at the end of the follow-up period did not afford any findings indicative of a specific test compound effect.

The LD 50 was found to be >2000 mg/kg bw (Andrews, 1996).

A study on the acute inhalation toxicity of the test substance in male and female Wistar rats has been conducted in accordance with OECD Guideline No. 403. Groups of rats were nose-only exposed for four hours to average vapour concentrations of 32, 47, 63, 125, and 184 mg/m³ air.

The LC50 for males and females combined was found to be ca. 47 mg/m³ air (Pauluhn, 1996).

Justification for classification or non-classification

The LC 50 of 47 mg/m³ leads to a classification requirement of R26.