Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-400-7 | CAS number: 58-86-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- OECD Toolbox v3.1
Toolbox prediction report is attached in IUCLID - GLP compliance:
- not specified
Test material
- Reference substance name:
- Xylose
- EC Number:
- 200-400-7
- EC Name:
- Xylose
- Cas Number:
- 58-86-6
- Molecular formula:
- C5H10O5
- IUPAC Name:
- (2S,3R,4S; 5R)-oxane-2,3,4,5-tetrol
- Details on test material:
- SMILES:C1(O)C(O)C(O)C(O)CO1
Constituent 1
Test animals
- Species:
- other: Rabbit; Human
Test system
- Type of coverage:
- other: no data; occlusive
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- < 2
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b") and("c" and "d") )
Domain logical expression index: "a"
Referential boundary:The target chemical should be classified as Neutral Organics by Aquatic toxicity classification by ECOSAR ONLY
Domain logical expression index: "b"
Referential boundary:The target chemical should be classified as Discrete chemical by Substance Type
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -3.9
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= -1.55
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Primary (Dermal) Irritation Index (PII): <2; Slightly irritating based on expert judgement
- Executive summary:
A Primary Irritation Index (PII) value less than 2 was derived by QSAR using the OECD Toolbox. The model was based on in vivo rabbit skin irritation using the five nearest neighbours. The test substance was determined to be slightly irritating to the skin based on expert judgement. Supporting documentation is provided in the attached prediction report..
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
