Registration Dossier
Registration Dossier
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EC number: 413-890-4 | CAS number: 82469-79-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Act CFR 16.1500.3 as described in National Academy of Science Publication #1138
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 413-890-4
- EC Name:
- -
- Cas Number:
- 82469-79-2
- Molecular formula:
- C28H50O8
- IUPAC Name:
- 1,2,3-trihexyl 2-(butanoyloxy)propane-1,2,3-tricarboxylate
Constituent 1
Test animals
- Species:
- other: Albino rabbit
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: none. Undiluted agent used.
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: All rabbits, with one exception, were alert and active and exhibited normal body weight gains and food consumptions. from day one through day 14 one female rabbit exhibited reduced food consumption, soft stool
- Gross pathology:
- Effects on organs:
None. - Other findings:
- Signs of toxicity (local):
Upon removal of the occlusive dressing following 24 hour
exposure, a very slight erythema (Grade 1) was seen in one
male with abraided skin. The erythema was seen on the
second day but was gone by the third day. No erythema or
edema was seen any of the other abraided or intact sites.
Very slight to slight desquamation of the episermis was seen
on days 6 and 7 after dosing at six intact and two abraided
sites of the ten sites but lasted on 1-3 days.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute dermal toxicity of Citroflex B-6 in rabbits is > 2 g/kg.
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