Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-453-6 | CAS number: 60-09-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 4-Aminoazobenzene. BUA-Stoffbericht 217
- Author:
- Beratergremium für Altstoffe (BUA)
- Year:
- 1 998
- Bibliographic source:
- BUA der Gesellschaft dt. Chemiker, S. Hirzel Wissenschaftliche Verlagsgesellschaft, Stuttgart
- Reference Type:
- publication
- Title:
- Metabolism of some dimethylaminoazobenzene derivatives
- Author:
- Robinson PJ, Ryan AJ, Wright SE
- Year:
- 1 964
- Bibliographic source:
- J Pharm Pharmacol 16: 80-2T
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-aminoazobenzene
- EC Number:
- 200-453-6
- EC Name:
- 4-aminoazobenzene
- Cas Number:
- 60-09-3
- Molecular formula:
- C12H11N3
- IUPAC Name:
- 4-[(E)-2-phenyldiazen-1-yl]aniline
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- C14-labeled 4-Aminoazobenzene
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- arachis oil
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 10 mg/rat Females: 10 mg/rat
- No. of animals per sex per dose / concentration:
- 3
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- no data
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: for 3 days
- From how many animals: (samples pooled or not): no data
- Method type(s) for identification:quantified after acid hydrolysis - Statistics:
- no data
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data
- Details on distribution in tissues:
- no data
- Details on excretion:
- urine
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- p-phenylenediamine (CAS #: 106-50-3)
p-aminophenol (CAS #: 123-30-8)
Any other information on results incl. tables
The excretion of p-aminophenol and p-phenylenediamine was almost completed already after 24 hours. Almost 100 % of the theoretical amount of p-aminophenol were recovered, while only a total of 20- 30% of the p-phenylenediamine was recovered.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
