4-aminoazobenzene

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication which meets basic scientific principles

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

4-Aminoazobenzene. BUA-Stoffbericht 217

Author:

Beratergremium für Altstoffe (BUA)

Year:

1998

Bibliographic source:

BUA der Gesellschaft dt. Chemiker, S. Hirzel Wissenschaftliche Verlagsgesellschaft, Stuttgart

Reference 2

Reference Type:

publication

Title:

Sensitization induced by patch testing

Author:

Agrup G

Year:

1968

Bibliographic source:

Br J Dermatol. 80: pp:631-634

Reference 3

Reference Type:

publication

Title:

Dermatitis from an azo-dye in industrial Ieather protective shoes

Author:

Ancona A, Serviere L, Trejo A, Monroy F

Year:

1982

Bibliographic source:

Contact Dermatitis 8: pp. 220-221

Reference 4

Reference Type:

publication

Title:

Contact dermatitis from a stamp-ink of the German post ofiice

Author:

Braun WPH

Year:

1975

Bibliographic source:

Contact Dermatitis 1, 189

Reference 5

Reference Type:

publication

Title:

Cosmetic intolerance

Author:

Broeckx W, et al.

Year:

1987

Bibliographic source:

Contact Dermatitis 16: 189-194

Reference 6

Reference Type:

publication

Title:

Contact dermatitis of the feet

Author:

Correia S, Brandao FM

Year:

1986

Bibliographic source:

Dermatosen Beruf Umwelt 34: 102-105

Reference 7

Reference Type:

publication

Title:

Textile dye dermatitis

Author:

Dooms-Goossens A

Year:

1992

Bibliographic source:

Contact Dermatitis 27: 321-323

Reference 8

Reference Type:

publication

Title:

Investigations of group allergies to aromatic aminocompounds [Untersuchungen zur Gruppenallergie bei aromatischen Amino- Verbindungen]

Author:

Düngernann H, Borelli S

Year:

1966

Bibliographic source:

Berufs-Dermatosen 14,281-295

Reference 9

Reference Type:

publication

Title:

Patch test results with a shoewear screening tray in 119 patients, 1977-1980

Author:

Lynde CW, Warshawski L, Mitchell JC

Year:

1982

Bibliographic source:

Contact Dermatitis 8: 423-425

Reference 10

Reference Type:

publication

Title:

Standard patch tests in agncultural workers.

Author:

Garcia-Perez A, et al.

Year:

1984

Bibliographic source:

Contact Dermatitis 10: 151-153

Materials and methods

Type of sensitisation studied:

skin

Study type:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-aminoazobenzene

EC Number:

200-453-6

EC Name:

4-aminoazobenzene

Cas Number:

60-09-3

Molecular formula:

C12H11N3

IUPAC Name:

4-[(E)-2-phenyldiazen-1-yl]aniline

Results and discussion

Any other information on results incl. tables

Numerous patient cohorts and occupationally exposed persons clearly reacted positively to 4-Aminoazobenzene in concentrations of 0.25 - 2 % in vaseline or methylethylketone in the epicutaneous test. Moreover, several case descriptions exist in which positive reactions by 4-Aminoazobenzene in concentrations of 0.25 - 5 % could be triggered in individuals with dermatitis.

(IUCLID, 1996: Arnold et al., 1995; Bruynzeel et al., 1983; Degreef et al., 1985; Dooms-Goossens et al., 1987; Foussereau et al., 1986; Goh and Kozuka, 1986; Hausen, 1994; Hjorth and Rothenborg, 1967; Katoh et al., 1986; Manzini et al., 1991; Matsunaga et al., 1990; Prens et al., 1986; Roeleveld and van Ketel, 1975, 1976; Saha et al., 1993; Schubert et al., 1987; Schulz, 1962; Seidenari et al., 1997; Thierbach et al., 1992; Thune, 1984; Uter et al., 1993, 1996).