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EC number: 427-720-1 | CAS number: 26364-65-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to OECD 105
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- -
- EC Number:
- 427-720-1
- EC Name:
- -
- Cas Number:
- 26364-65-8
- Molecular formula:
- C4H5N3S
- IUPAC Name:
- [(1,3-thiazolidin-2-ylidene)amino]formonitrile
- Details on test material:
- name: Cyanamide, (4,5-dihydroxy-2-thiazolyl)-
molecular formula: C4 H5 N3 S
molecular weight: 127.2
physical state: solid
analytical purity: 99.8 %
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 7 g/L
- Temp.:
- 20 °C
- pH:
- ca. 6.61 - ca. 7.03
Any other information on results incl. tables
| acidic | neutral | pH5.5-7 | alkaline | |||||||
| phosphate buffer | phosphate buffer | unbuffered water | borate buffer | |||||||
| c(NaH2P04 x2H2O) = 0.01 Mole/L | adjusted to pH 5 with conc. NaOH | c(Na2HPO4x12H2O) = 0.01 Mole/L adjusted to pH 7 with conc. H3PO4 | in equilibrium with atmospheric carbon dioxide | c(Na2B4O7x10H2O) = 0.01 Mole/L | ||||||
| PH | 5.0 | 7.1 | (6.8) | 8.6 | ||||||
| stirring time | pH | [ g / L ] | pH | [ g / L ] | pH | [ g / L ] | pH | [ g / L ] | ||
| 0.5 hrs. | 5.81 | 7.5598 | 7.26 | 7.7504 | 6.61 | 7.1225 | 8.69 | 8.6353 | ||
| 1 hr. | 5.25 | 7.9123 | 7.37 | 7.8418 | 6.90 | 7.0268 | 8.46 | 8.8018 | ||
| 2 hrs. | 5.47 | 8.3661 | 7.19 | 8.1626 | 6.70 | 7.7188 | 8.59 | 8.9372 | ||
| 4 hrs. | 4.65 | 7.5388 | 7.12 | 7.9965 | 6.67 | 7.8048 | 8.59 | 9.3456 | ||
| 8 hrs. | 4.51 | 8.1458 | 7.15 | 8.0227 | 6.71 | 8.3756 | 8.59 | 9.4446 | ||
| 24 hrs. | 4.37 | 7.5120 | 7.19 | 7.9793 | 6.91 | 7.7546 | 8.60 | 8.6813 | ||
| 48 hrs. | -- | -- | -- | -- | 7.03 | 7.8898 | -- | -- | ||
| 144 hrs. | -- | -- | -- | -- | -- | -- | 8.99 | 8.2552 | ||
| mean | 7.84 | 7.96 | 7.67 | 8.87 | ||||||
| R.S.D. | 4.6% | 1.8% | 6.0% | 4.7% | ||||||
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The solubility of CIT is 7.7 g/L. - Executive summary:
The water solubility determined at 20 °C and as a function of pH according to the OECD
Guidelines No. 105 corresponding to EC Guideline A.6 as described under flask method gave the
following results:
unbuffered pH5 pH7 pH9 solubility 7.7 g/L 7.8 g/L 8.0 g/L 8.9 g/L
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