Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

developmental toxicity
Type of information:
Adequacy of study:
disregarded due to major methodological deficiencies
3 (not reliable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
The predicted compound is outside the Applicability Domain of the model.
Justification for type of information:
Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is shown in the attached document as well (QPRF). QSAR model reporting format is shown in the QMRF file attached.

Data source

Reference Type:
other: QSAR model
VEGA in silico platform
Bibliographic source:
Developmental/Reproductive Toxicity library (PG) 1.1.2

Materials and methods

Test guideline
equivalent or similar to guideline
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Constituent 1
Chemical structure
Reference substance name:
Cas Number:
Molecular formula:
Specific details on test material used for the study:

Results and discussion

Overall developmental toxicity

Developmental effects observed:

Any other information on results incl. tables

The prediction was deemed to be not reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.

Applicant's summary and conclusion

The substance was predicted to be NON-Toxicant, but the result may be not reliable.
The predicted compound is outside the Applicability Domain of the model.