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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14th April 2022
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2022
Report date:
2022

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Potassium hydrogen fluoride, reaction product with boric acid and dipotassium salt of boric acid
Cas Number:
2787482-26-0
Molecular formula:
not applicable (UVCB)
IUPAC Name:
Potassium hydrogen fluoride, reaction product with boric acid and dipotassium salt of boric acid
Test material form:
solid - liquid: suspension

In vitro test system

Test system:
artificial membrane barrier model
Justification for test system used:
The Corrositex® test is an internationally accepted (1)(2)(3) validated test method for skin corrosion according to Globally Harmonized System (GHS) classifications
Vehicle:
unchanged (no vehicle)
Control samples:
yes, concurrent negative control
yes, concurrent positive control
Amount/concentration applied:
500 µl to each replicate
Duration of treatment / exposure:
Each replicate was observed until the membrane was destroyed
Number of replicates:
4

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
1
Value:
50 - 58
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
2
Value:
50 - 58
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
3
Value:
50 - 58
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
4
Value:
50 - 58
Vehicle controls validity:
not applicable
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
The findings of the performed study lead to the designation of this sample as a UN Packing Group III/GHS 1C.
Executive summary:

A single sample was analyzed by the Corrositex method to determine its corrosive potential and GHS and U.N. Packing Group designations.
The results of this study indicated that the sample was compatible with the Corrositex system and was classified as a Category 2 material. The results obtained from the evaluation of four replicate samples were difficult to identify at a precise moment. It took a while to develop a visible color formation. A breakthrough time between 50 and 58 minutes from four replicates was observed to destroy the synthetic biobarriers.