Registration Dossier
Registration Dossier
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EC number: 619-799-8 | CAS number: 66309-83-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct -Nov 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-dimethyl-2,3-dihydro-1H-inden-1-one
- EC Number:
- 619-799-8
- Cas Number:
- 66309-83-9
- Molecular formula:
- C11H12O
- IUPAC Name:
- 2,6-dimethyl-2,3-dihydro-1H-inden-1-one
Constituent 1
- Specific details on test material used for the study:
- Purity: 95.3%
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tap water with the aid of 2% Cremophor EL
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 animals, two replicates
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities.
- Clinical signs:
- other: The clinical signs were decreased motility, uncoordinated gait and reactivity decreased.
- Gross pathology:
- A dose of 2000 mg/kg body weight was tolerated by female rats without gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item has not to be classified for acute oral toxicity.
- Executive summary:
A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities, effects on weight gain and gross pathological findings.
The clinical signs were decreased motility, uncoordinated gait and reactivity decreased.
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