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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
12 Dec 1988 - 9 Feb 1989
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Directive 84/449/EEC Method A.7
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
404-740-9
EC Name:
-
Cas Number:
115895-09-5
Molecular formula:
C26H40Cl2O5
IUPAC Name:
ethyl 3,5-dichloro-4-{[(hexadecyloxy)carbonyl]oxy}benzoate
Details on test material:
- Name of test material (as cited in study report): AF-366
- Physical state: solid

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
standard fat
Remarks:
fat simulant HB 307
Solubility:
87 072 mg/100 g solvent
Temp.:
37 °C
Remarks on result:
other: 87072 ± 6589 mg/100 g solvent

Any other information on results incl. tables

The test substance is highly soluble in fat.

Details:

Table 1.

Sample

Weight of the fat solution [g]

Solubility (S’) [mg/100 g fat solution]

Solubility (S) [mg/100g fat]

Series I

Ia

0.09471

47108

89065

Ib

0.11980

42569

74122

Ic

0.11417

46607

87290

Id

0.09250

47301

89768

Mean value Series I

85061 ± 7367

Series II

IIa

0.08988

46331

86327

IIb

0.11775

46848

88140

IIc

0.12106

45681

84098

IId

0.11412

49435

97765

Mean value Series II

89083 ± 6020

Mean of all values

87072 ± 6589

Applicant's summary and conclusion