Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 AUG 2022 TO 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- October 2012
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
- Version / remarks:
- June 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- air comparison pycnometer (for solids)
Test material
- Reference substance name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Cas Number:
- 1950587-17-3
- Molecular formula:
- C12H11F3N4O
- IUPAC Name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: JNJ-63632283-AAA (T003665)
- Physical state: solid (powder)
- Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22BN0551
- Expiry date: 28 April 2023 (retest date)
- Physical Description: Off-white powder
- Purity: 98.3%
- Purity correction factor: no correction factor required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: prior to use in the study, the test material was dried in a desiccator under vacuum using silicagel as the drying agent at 21.7 ± 0.8°C in dark for 46 hours.
Results and discussion
Densityopen allclose all
- Key result
- Type:
- density
- Density:
- 1.5 g/cm³
- Temp.:
- 20 °C
- Remarks on result:
- other: The individual measurements were obtained with an accuracy of < 0.02 g/cm³. According to the guideline, the density of the test material is given as the mean value.
- Key result
- Type:
- relative density
- Density:
- 1.5
- Temp.:
- 20 °C
Any other information on results incl. tables
The results of the tests on the determination of the density of the test material are given in the table below
Density of the Test Material
| Test 1 | Test 2 |
Sample mass (g) | 3.8547 | 4.2242 |
Sample volume (cm3) | 2.5715 2.5662 2.5689 2.5698 2.5694 | 2.8368 2.8316 2.8355 2.8323 2.8341 |
Average volume (cm3) | 2.5692 ± 0.0017 | 2.8341 ± 0.0019 |
Density [g/cm3] | 1.500 | 1.491 |
Mean Density (g/cm3) | 1.50 | |
Applicant's summary and conclusion
- Conclusions:
- A gas comparison stereopycnometer was used for the determination of the density and relative density of JNJ-63632283-AAA (T003665).
The density of the test material at 20ºC was 1.50 g/cm³ (1.50E03 kg/m³).
The relative density was 1.50.
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