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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 Jan - 23 Mar 1993
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Dissociating properties:
yes
No.:
#1
pKa:
7.57
Temp.:
25 °C

95% confidence interval 7.51 to 7.63


 


Validity criteria for the measurement of the dissociation constant:




















Target condition according to guideline:Actual condition according to the study:Validity criteria met:
The dissociation constant should be replicated (a minimum of three determinations) to within ± 0.1 log units.

Three measuements were done and results were within ± 0.1 log units.


yes
The temperature should be controlled to at least ± 1°C. The determination should preferably be carried out at 20°C.

The test was performed at 25°C ± 1°C.


no

 


 

Conclusions:
The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.
Executive summary:

The study was performed to assess the dissociation constant. The study was conducted in accordance with the OECD guideline 112. The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.

Description of key information

The study was performed to assess the dissociation constant. The study was conducted in accordance with the OECD guideline 112. The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.

Key value for chemical safety assessment

Additional information

pKa 7.58 at 25 °C