Registration Dossier
Registration Dossier
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EC number: 419-050-3 | CAS number: 79944-37-9 AMINODIOXEPAN
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Jan - 23 Mar 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 7.57
- Temp.:
- 25 °C
- Conclusions:
- The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.
- Executive summary:
The study was performed to assess the dissociation constant. The study was conducted in accordance with the OECD guideline 112. The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.
Reference
95% confidence interval 7.51 to 7.63
Validity criteria for the measurement of the dissociation constant:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| The dissociation constant should be replicated (a minimum of three determinations) to within ± 0.1 log units. | Three measuements were done and results were within ± 0.1 log units. | yes |
| The temperature should be controlled to at least ± 1°C. The determination should preferably be carried out at 20°C. | The test was performed at 25°C ± 1°C. | no |
Description of key information
The study was performed to assess the dissociation constant. The study was conducted in accordance with the OECD guideline 112. The dissociation constant of the substance is 7.57 ± 0.04 at 25 °C.
Key value for chemical safety assessment
Additional information
pKa 7.58 at 25 °C
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