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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl is an UVCB which doesn't present any alerts in genotoxicity, systemic toxicity and isn't subject to any bioaccumulation potential. Thus, a toxicokinetic study might be unrealistical since producing the benchmarks for the test is a limitating factor.
Reason / purpose for cross-reference:
read-across source
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Due to the cationic profile, a published article on cetrimonium bromide is a reliable data evidence to sustain our rational:
Objective of study:
Principles of method if other than guideline:
Assessing the bioavailability of a cationic surfactant using radiolabeled element
not specified
not specified
Route of administration:
other: oral and intraveneous
Due to the high water solubility
Details on exposure:
14C-labelled cetrimonium bromide: 0.8 mg/kg by oral gavage
14C-labelled laurtrimonium bromide: single intravenous injection of 0.5 ml of a 0.023% solution in saline
Preliminary studies:
The conclusion from both studies are as follows:

1)-Cetrimonium bromide shows to be poorly absorbed in the gastro-intestinal tract and not readily metabolized in the rat body.
2)-Only small amounts of radioactivity were found in other organs and there was no sign of accumulation of radioactivity in any organ.
Interpretation of results (migrated information): other: Bioaccumulation is not expected
Based on the toxicological profile, one can assume that these common metabolites will be included in the physiologic processes and metabolised accordingly. Concerning excretion, an extensive metabolism, leading to polar metabolites with low molecular weights, followed by renal excretion is to be expected
Therefore there is no potential of bioaccumulation of the constituents of this mixture.
Executive summary:

The toxicokinetic evaluation of 1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl based both on its intrinsic profile and 2 published acticles corroborated with our assesment .

All taken togheter, one is confortable concluding that 1-Propanaminium,3-(1-oxododecyl)-amino-N-(2-((2-hydroxyethyl)amino)-2-oxoethyl)-N,N-dimethyl is not expected to bioaccumulate in the organisms.


Bartnik, F.G., and Wingen, F. (1979). Percutaneous absorption of dodecyltrimethylammonium bromide, a cationic surfactant, in the rat. Food Cosmet. Toxicol. 17, 633-637

Isomaa, B. (1975) Absorption, distribution and excretion of [14C]CTAB, a quaternary ammonium surfactant, in the rat. Fd. Cosmet. Toxicol. 13, 231-237

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
{[(2-hydroxyethyl)carbamoyl]methyl}dimethyl(3-octadecanamidopropyl)azanium chloride

Results and discussion

Applicant's summary and conclusion