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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

The acute toxicity of the test material to the freshwater invertebrate Daphnia magna has been investigated and gave a 48 hour EC50 of greater than 0.80 mg/l. Correspondingly the No Observed Effect Concentration was 0.80 mg/l.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.8 mg/L

Additional information

Preliminary solubility work and analysis showed that at a test concentration of 0.80 mg/l a proportion of the test material remained undissolved. Therefore analysis was performed on samples of filtered and unfiltered test media during the definitive study. The filtered samples indicated the concentration of test material in solution and hence bioavailable to the test organisms.

Analysis of the unfiltered media showed measured values of 72% and 67% of nominal at 0 hours and 82% and 80% at 48 hours. The low results shown for the 0 hour test samples were considered to be due to the problems associated with sampling and analysis of dispersions at low test concnetrations in a complex biological system, such as adsorption to the test organisms and their waste. Analysis of frozen duplicate samples showed lower measured values from those originally obtained. This was considered to be due to losses during storage and thawing prior to analysis. Analysis of the filtered test media showed measured test concentrations of 3% of nominal at 0 hours and 6% of nominal at 48 hours.

The results shown from analysis of the unfiltered media indicate both the amount of dispersed and dissolved test material in the system, whereas the measured values from the filtered media indicate the amount of dissolved test material which was bioavailable to the test organisms. It was therefore considered appropriate to base the results on the time-weighted mean measured test concentrations of the filtered test media in order to give a worse case analysis of the data.