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Diss Factsheets
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EC number: 432-770-2 | CAS number: 139189-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The partition coefficient of the substance was measured to be >6.2 by means of the HPLC method. The limit value is due to the limitation of the method. It was therefore considered appropriate to undertake an estimation of the partition coefficient by means of QSAR estimation based upon the SMILES code of the molecule using US EPA KOWWIN v1.67 of the EPI Suite v4. Based upon structural fragmentation drawn from a database of >40,000 substances, including aryl phosphate esters and aromatic species predicted for the fragmentation estimates, the log Pow is estimated to be 11.79.
Based on these data, the substance may be considered to be of concern as potential for bioaccumulation, according to screening criteria for bioaccumulation in ECHA guidance (Chapter R.11 PBT Assessment). The likely reliability of the log Pow is, however, considered to diminish above a value of 6, as noted in Appendix R.11-1 Annex 1 of ECHA guidance on PBT Assessment. Substances with log Pow between 4.5 and 6 are considered likely to be highly accumulating; however no substantial bioconcentration is assumed for compounds having log Pow with values less than 4.5 or greater than 6. For compounds having log Pow greater than 6, a gradual decrease of the BCF is observed and it has been hypothesised within the published literature that a high log Pow is more an effect of solubility than a tendency of the substance to be lipophilic.
Considering that the measured log Pow is a limit value at 6.2 and has been estimated based on structure to be 11.79, it is considered that the results indicate that the substance is likely to be non-bioaccumulating based on the partition coefficient.
A fish bioaccumulation study has been conducted using common carp and according to the OECD 305 test guideline which concludes that the BCF is <0.02 based on whole body weight after 56 days. The study was, however, conducted primarily for notification in Japan and, due to the low water solubility, the test formulations were prepared using a dispersing agent of 3%v/v Tween 80-dimethylformamide. The use of a dispersing agent is considered to affect the uptake of the test item to the fish reducing the reliability of the result.
In support of these data, two separatein silicoQSAR estimations have been undertaken using the EPIWIN and CAESAR database systems. The EPIWIN QSAR estimates that the BCF for the substance is 8.99 L/Kg while the CAESAR QSAR estimates the BCF for the substance to be 6 L/Kg. These data support the consideration that the use of the dispersing agent affects the uptake of the substance to the test organism but suggest that the BCF for the substance is below the threshold of concern.
Summary:
Based on a weight of evidence approach of study data with reduced reliability and two separate QSAR estimation techniques, PX-200 is considered to be not bioaccumulative with a BCF <100. It is, therefore, considered to not meet the DSD criteria of ≥ 100 nor the CLP criteria of ≥ 500.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.