(8α,9R,8'''α,9'''R)-1,1'-[(2,3,5,6-tetrafluoro-1,4-phenylene)bis(methylene)]bis(6'-methoxycinchonan-1-ium-9-ol) dibromide

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Key result

Test no.:

#1

Temp.:

40 °C

Vapour pressure:

< 0 Pa

Key result

Test no.:

#2

Temp.:

40 °C

Vapour pressure:

< 0 Pa

Key result

Test no.:

#3

Temp.:

40 °C

Vapour pressure:

< 0 Pa

Conclusions:

The vapour pressure of the substance has been found to be less than 2E-06 Pa at 25 °C.

Executive summary:

The vapour pressure of the substance was studied under GLP to OECD TG 104 by a gas saturation method. For each of three saturator columns, approximately 200 mg of the test item was weighed into a round bottomed flask and approximately 20 g of 2 mm diameter glass beads added. The test item was then vigorously mixed with the glass beads on a vortex mixer. A glass wool plug was placed at the outlet of each saturator column. The coated glass beads were then loaded into the saturator columns and a second glass wool plug placed also at the inlet of each saturator column.

The saturator columns were connected to the nitrogen supply and a stream of nitrogen was passed through the saturator columns at three different flow rates (30, 40 and 50 mL/minute) to ensure saturation control. The saturator columns were then equilibrated at 40 °C for approximately 21 hours to remove any volatile impurities.

Finally two condensation tubes, cooled in an ethylene glycol/water mixture at approximately -12 °C to -15 °C, were connected in series to the outlet of each of the three saturator columns.

A determination was performed at a gas temperature of 40 °C, with gas flow time of 121.9 hours. After completing the test, the condensation tubes were disconnected from the saturator columns and the amount of transferred test item in each of the tubes determined analytically. The concentration of test item in the sample solutions was determined by high performance liquid chromatography (HPLC).

The vapour pressure of the substance was found to be less than 2.0E-06 Pa at the test temperature of 40 °C and thus must also be less than 2.0E-06 Pa at 20 and 25 °C.

Description of key information

Vapour pressure <2.0E-06 Pa at 25 °C (GLP, OECD TG 104)