(8α,9R,8'''α,9'''R)-1,1'-[(2,3,5,6-tetrafluoro-1,4-phenylene)bis(methylene)]bis(6'-methoxycinchonan-1-ium-9-ol) dibromide

Density

Link to relevant study record(s)

Reference

Endpoint:

bulk density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

2012

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Key result

Type:

bulk density

Density:

1.48 g/cm³

Temp.:

20 °C

Table 1: Experimental results obtained with the gas pycnometer

Determination	Test	P1 (psig)	P2 (psig)	Volume (cm3)	Density (kg/m3)	Mean density (kg/m3)
1	A	17.060	6.904	15.307	1.54 x 10^3	1.48 x 10^3
	B	17.259	7.002	15.869	1.48 x 10^3
	C	17.047	6.919	15.967	1.47 x 10^3
2	A	17.087	6.835	12.671	1.53 x 10^3	1.48 x 10^3
	B	17.231	6.908	13.180	1.47 x 10^3
	C	17.160	6.878	13.129	1.48 x 10^3

Conclusions:

The mean density of the test substance was determined to be 1.48 g/cm3 at 20 ± 0.5 °C.

Executive summary:

The density of the substance was determined under GLP with a gas comparison pycnometer method in accordance with OECD TG 109. This method allows the determination of the exact volume of a solid sample, and through the known mass of the sample taken, also the density of the sample. The gas comparison pycnometer consists of two interlinked cells (reference and sample cell) of fixed volume, which can be pressurised with helium as inert gas also demonstrating ideal gas behaviour. The volume of the reference and sample cells were determined using a stainless steel calibration sphere of certified volume. The reference cell was then pressurised to a typical pressure in the range from 16 to 20 pounds per square inch gauge, which was the pressure determined by the test instrument as monitored by an internal transducer. Aliquots of test substance (23.5271 and 19.4084 g) were weighed into the sample cell, which was then placed into the reference cell. This resulted in a pressure drop, which was recorded. Triplicate readings of the pressure drop were taken for each of the two determinations. The determined volumes of the reference and sample cells were within the defined tolerance of 90.953 ±. 1.0 and 149.225 ± 1.0 cm3 for the reference and sample cells, respectively and the gas comparison pycnometer was considered suitable for use. The mean density of test substance determined with the method was 1.48 g/cm3 at 20 °C ± 0.5 °C.

Description of key information

Density = 1.48 g/cm3 at 20 °C ± 0.5 °C (GLP, OECD TG 109)

Key value for chemical safety assessment

Relative density at 20C:

1.48