Registration Dossier
Registration Dossier
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EC number: 613-906-1 | CAS number: 66212-25-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September to October 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1981
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 17-Hydroxy-1,4,6-pregnatriene-3,20-dione
- EC Number:
- 613-906-1
- Cas Number:
- 66212-25-7
- Molecular formula:
- C21 H26 O3
- IUPAC Name:
- 17-Hydroxy-1,4,6-pregnatriene-3,20-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg (application volume 10 mL/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No animal died in the course of the study. Moreover, no clinical signs, no effects on body weight and body weight gain and no abnormalities at necropsy were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is of low oral toxicity.
- Executive summary:
The single oral administration of the test substance (ZK 5668) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs and effects on body weight were observed and there were no macroscopic pathological signs.
The acute oral toxicity of 1,4,6 -Trienol in rats is therefore above 2000 mg/kg body weight.
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